Saturday, March 8, 2014

Oxadiazoles: an anti-adaptive



http://www.sciencedaily.com/releases/2014/03/140307165953.htm
(highlight and right click to go to website)

summary(summarized by the university of Notre Dame on march 7th 2014): A new class of antibiotics to fight bacteria such as methicillin-resistant Staphylococcus aureus and other drug-resistant bacteria that threaten public health has been discovered by a team of chemists. The new class, called oxadiazoles, was discovered in silico (by computer) screening and has shown promise in the treatment of MRSA in mouse models of infection. MRSA has become a global public-health problem since the 1960s because of its resistance to antibiotics. In the United States alone, 278,000 people are hospitalized and 19,000 die each year from infections caused by MRSA. Only three drugs currently are effective treatments, and resistance to each of those drugs already exists.

Relevance: This article is relevant to our study of the resistance of antibiotics to the medicines of today. MRSA is a bacteria that has adapted to many of the antibiotics that we commonly use to treat bacteria, such as penicillin. What is interesting about this new class of antibiotics is that it does not kill the bacteria, but "reverses" the adaptations to common drugs so that other drugs can treat is. It is also relevant because this new class of antibiotics is not just an antibiotic, but also is an anti-adaptive(I made that word up) 


2 comments:

  1. What are the 3 drugs that already exist to treat MRSA?

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    Replies
    1. Bactrim and Vancomycin are often the first drugs used, but other options are clindamycin, minocycline, Tygacil, Cubicin, Zyvox, and Synercid. Unfortunately, there is emerging resistance to a lot of these antibiotics beginning to show. Antibiotics are not always necessary either. If you have a skin boil caused by MRSA, a doctor may be able to make an incision and drain it.(webMD.com)

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